Niacinamide is a form of vitamin B3 with quite a simplistic but powerful benefits- profile. It costs $5 for a bottle. It is the healthiest and safest form of B3 since the other form, nicotinic acid AKA niacin, increases serotonin and prostaglandins, increasing inflammation, and degranulates mast cells, increasing allergies. Niacin is liver-toxic, causes severe flushing, and lowers cholesterol, which is bad since the beneficial cholesterol is needed to form protective neurosteroids. It also speeds up liver phase 1 metabolism, increasing chemical sensitivity.
Niacinamide does the opposite. It reduces serotonin and prostaglandins so is anti-inflammatory, stabilizes mast cells, reducing allergies, and slows down liver phase 1 metabolism, reducing chemical sensitivity. Niacinamide energizes mitochondria, improves brain and gastrointestinal healing, and protects against the toxic free fatty acids and nitric oxide. It spares liver glycogen storage, improving metabolism and is a potent antifungal effective for candida in only a single dose of 35 mg/kg.
Histone deacetylases are enzymes increasingly found to be involved in causing physical and mental illness. Histone deacetylase inhibitors (HDIs) have long been used in psychiatry and neurology as mood stabilizers and anti-epileptics, and are now being researched as potential treatments for cancer, parasitic, inflammatory, and neurodegenerative diseases like Alzheimer’s and Huntington’s, and as a method to extend lifespan. Niacinamide is a cheap and powerful histone deacetylase inhibitor.
Niacinamide suppresses cancer growth, silences the cancer-causing hormone estrogen, and improves the tumor suppressing gene, p53.
In stress, trauma, and depression, brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), which regulate neuron growth and health, are downregulated. Histone deacetylase inhibitors like niacinamide upregulate BDNF and GDNF. Animals treated with HDIs improved as much or better than those treated with Prozac.
Persistent or treatment-resistant depression involves brain adaptations and changes in gene expression, which are caused by stressors like social defeat and learned helplessness. Histone deacetylase is closely involved in these maladaptive conditions. Thus, HDIs like niacinamide can effectively reverse this kind of depression.
HDIs like niacinamide decrease preference for addictive substances like nicotine without creating aversion, allowing free choice.
By agonizing GABA, niacinamide prevents anxiety and seizures, relaxes muscles, reduces aggression, and lowers the stress hormone cortisol, making it similar to but much safer than benzodiazepines. It’s HDI ability enhances fear extinction in anxiety disorders. Socially anxious and subordinate rats given niacinamide became confident and popular. Researchers linked this to niacinamide’s mitochondrial benefits.
An adult woman on a social anxiety support forum reported that 1500 mg niacinamide daily cured her panic attacks and phobias, and returned three years after her original post to confirm persistent recovery (“Niacinamide cure“).
By inhibiting the estrogenic SIRT1 gene, niacinamide increases dihydrotestosterone (DHT), increasing libido and genital health.
Niacinamide is beneficial to the skin, reducing dryness, hyperpigmentation, scarring, and photoaging.