Serotonin and the Kynurenine Problem

It's possible that Ray Peat’s classification of serotonin as primarily an inflammatory mediator is largely due to the tryptophan → kynurenine pathway that happens during inflammation, and everything bad that kynurenine metabolites do is almost all blamed on serotonin (Haq, et al., 2021). Problems with serotonin metabolism can largely be explained by activation of the … Continue reading Serotonin and the Kynurenine Problem

Preserving your Mind in the Age of Hyperstimuli

We are living through a pandemic of psychiatric illness—depression, ADHD, personality disorders, and resulting psychosocial carnage and suicide, are on the rise; directly linked to electronic devices and social media, the severity of symptoms is seen to increase in proportion to the amount of a person’s screen time.  These maladies have especially increased since the … Continue reading Preserving your Mind in the Age of Hyperstimuli

Endotoxin’s Role in Degeneration and Disease; Protective Factors to Mitigate it

Lipopolysaccharides, also called endotoxins, are structural components of bacteria that are released in the intestine and safeguarded against by an optimal physiology and the integrity of the intestinal barrier, but unhealthy lifestyles, bad eating habits, genetic predispositions, or infections can increase endotoxin concentration to intolerable levels, or make us more sensitive to “normal” levels, for … Continue reading Endotoxin’s Role in Degeneration and Disease; Protective Factors to Mitigate it

Resistant Depression Advice: Effective OTC & Rx Treatments

If your depression is persistent, or treatment-resistant, there is a physiological malfunction going on that needs to be addressed. It is not genetic or permanent or “just the way you are”. No, ask yourself how rational it is to hypothesize that inherited, pro-survival genes would set you up to essentially succumb to death. If depression … Continue reading Resistant Depression Advice: Effective OTC & Rx Treatments

Niche Anhedonia Treatments

Anhedonia is one of the worst tortures known to man. Originating from the Greek ἀv- an-, "without" and hēdonē, "pleasure", anhedonia is the inability to feel pleasure, the inability feel anything good. Sufferers who don't know the word will usually describe it as a zombie-like state, feeling like a robot, feeling numb, feeling disconnected, or … Continue reading Niche Anhedonia Treatments

Solutions for Dissociation, Trauma, and Related Disease

Stressors, mental and physical, are an everyday encounter necessary for growth and change but trauma inhibits these. Think of your muscles: stress is a strain, it can wear you out; extreme or inescapable stress is trauma; it is an injury, a wound causing long-term or permanent damage. You are changed after trauma. Most people will … Continue reading Solutions for Dissociation, Trauma, and Related Disease